Ergotamine derivatives: Considering the theoretic odds of ergotism, the concurrent usage of azithromycin having ergot types isn’t required (discover hop over to the website point cuatro.4).
Even though neutropenia might have been associated with use of rifabutin, an effective causal link to consolidation with azithromycin hasn’t been established (get a hold of Area 4
Warning is advised on co-administration of those drugs having Azithromycin of the known enhancing effectation of these drugs whenever made use of in addition on the macrolid antibiotic drug erythromycin.
Co-administration out of atorvastatin (10 milligrams every day) and you can azithromycin (500 milligrams every day) failed to change the plasma concentrations away from atorvastatin (predicated on a great HMG CoA-reductase suppression assay). Yet not, post-revenue instances of rhabdomyolysis in the people finding azithromycin that have statins provides been said.
In an effective pharmacokinetic interaction research for the fit volunteers, zero tall impact is actually noticed for the plasma amounts of carbamazepine otherwise their energetic metabolite in the people receiving concomitant azithromycin.
Regardless of if good causal matchmaking hasn’t been based, thought should be given to the brand new regularity out-of monitoring prothrombin day whenever azithromycin is employed inside clients finding coumarin-kind of dental anticoagulants
Cisapride is metabolized regarding the the liver because of the chemical CYP 3A4. As the macrolides inhibit it enzyme, concomitant management out of cisapride might cause the rise of QT interval prolongation, ventricular arrhythmias and you may torsades de pointes.
For the a pharmacokinetic data examining the consequences of just one dose regarding cimetidine, given couple of hours just before azithromycin, towards pharmacokinetics away from azithromycin, zero alteration out of azithromycin pharmacokinetics try seen.
During the an effective pharmacokinetic interaction investigation, azithromycin don’t replace the anticoagulant effectation of just one fifteen mg amount away from warfarin applied to fit volunteers. There are accounts acquired on the post-business age potentiated anticoagulation after co-management regarding azithromycin and you can coumarin-variety of dental anticoagulants.
In a pharmacokinetic study with healthy volunteers that were administered a 500 mg/day oral dose of azithromycin for 3 days and were then administered a single 10 mg/kg oral dose of cyclosporin, the resulting cyclosporin Cmaximum and AUC0-5 were found to be significantly elevated. Consequently, caution should be exercised before considering concurrent administration of these drugs. If co-administration of these drugs is necessary, cyclosporin levels should be monitored and the dose adjusted accordingly.
Co-government regarding a good 600 mg solitary amount out-of azithromycin and you will eight hundred milligrams efavirenz every day getting 7 days didn’t produce people clinically extreme pharmacokinetic relationships.
Co-administration of a single dose of 1200 mg azithromycin did not alter the pharmacokinetics of a single dose of 800 mg fluconazole. Total exposure and half-life of azithromycin were unchanged by the co-administration of fluconazole, however, a clinically insignificant decrease in Cmax (18%) of azithromycin was observed.
Co-management of a single serving regarding 1200 milligrams azithromycin had no statistically extreme impact on brand new pharmacokinetics of indinavir applied because the 800 mg 3 x each and every day for 5 days.
In the fit volunteers, co-management out of azithromycin five hundred milligrams/date to have three days did not end in clinically tall alterations in the fresh pharmacokinetics and you may pharmacodynamics of one 15 milligrams dose out of midazolam.
Co-administration off azithromycin (1200 mg) and you may nelfinavir from the steady-state (750 milligrams 3 x day-after-day) resulted in improved azithromycin concentrations. No clinically extreme side effects was seen without serving improvement required.
In normal healthy male volunteers, there was no evidence of an effect of azithromycin (500 mg daily for 3 days) on the AUC and Cmax of sildenafil or its major circulating metabolite.
Pharmacokinetic studies have claimed no proof of a relationships between azithromycin and you will terfenadine. There had been rare circumstances reported the spot where the chances of such as for example a connection could not become completely omitted; although not there is zero particular facts one particularly an interaction had happened.
