Controversial results have been reported about the association of calcium, magnesium, and phosphorus and stroke risk, but none in China. To investigate the association between dietary calcium, magnesium, phosphorus, and stroke incidence in Chinese adults, we collected data from the China Health and Nutrition Survey (CHNS) from 2004 to 2011, including 6411 participants aged 45–79 years and free of stroke at baseline. Diet was assessed by interviews combining 3-d 24-h food recalls and household food inventory weighing at each survey round. The stroke incident was identified based on the validated self-report. Multivariate Cox regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). For 32,024 person-years of follow-up, 179 stroke cases were documented. After adjustment for major lifestyle and dietary risk factors, calcium intake was positively associated with reduced stroke risk, and the HR of stroke comparing extreme quartiles was 0.53 (95% CI 0.29–0.96, Pdevelopment = 0.03). In further stratified analyses, significant heterogeneity across sex strata was found (Pinteraction = 0.03). Dietary calcium intake among men was more inversely related to stroke, with HRs being 0.33 (95% CI 0.15–0.76, P trend = 0.02), compared to 1.24 (95% CI 0.46–3.35, Ptrend = 0.89) among women. However, no significant association between stroke and magnesium or phosphorus was revealed. Our findings suggest that higher dietary calcium intake was associated with a lower risk of stroke in Chinese adults, particularly in men.
Addition
While the a great cerebrovascular situation, heart attack is amongst the best reason behind demise for the create and you will development places. A great ten% overall annual dying around the world is projected become attributable so you can it step 1 . Probably the coronary arrest survivors, everything 15–30% try permanently handicapped 2 , which results in whenever 113 mil impairment-adjusted lifestyle many years lost 3 . Asia contains the high estimated existence likelihood of coronary arrest in the world (39.3%) depending on the 2016 worldwide burden from condition (GBD) local research cuatro . Seem to, heart attack happens to be a critical social ailment to possess China within the facing the increased ageing society. For this reason, pinpointing brand new convertible chance products try clicking towards avoidance and the advance of existence top-notch coronary attack clients and also the prevention regarding massive socio-financial burden.
Diet calcium, magnesium, and you may phosphorus consumption and you can risk of coronary attack when you look at the Chinese grownups
Even though the perfect etiology isn’t entirely elucidated, coronary attack could be believed an illness connected with genetic and you may environmental exposure products (particularly weight-loss) and/or interplay of these factors. Detailed evidence shows that diet variations are advantageous to prevent this new start of coronary attack 5,6,eight . A virtually relationship can be found anywhere between calcium supplements, magnesium, phosphorus, and you will vascular defense, that are thought extremely important health implications having vascular disorder simply because they is also regulate vascular calcification and you can endothelial malfunction 8,9 . Up to now, multiple studies have examined the connection anywhere between these types of nutrients intake and you may coronary arrest chance ten,eleven,twelve , nevertheless answers are inconsistent. Such as, search on the Western european society showed magnesium intake, not calcium was significantly associated with a lowered chance of heart attack 11 . Alternatively, in the us, calcium supplements consumption, in place of magnesium, causes ong people, magnesium consumption are inversely of the stroke twelve . In addition, most of these studies was basically presented during the west populations with high intakes of these vitamins 13,fourteen . But not, to your education, nothing is well known in regards to the association away from weight loss calcium supplements, magnesium, and you can phosphorus consumption with coronary attack chance regarding Chinese populace. An average weight-loss intake of them micronutrients among Chinese some one drinking mostly bush-built diets try said to be less than that of Europeans kod promocyjny marriagemindedpeoplemeet and you will Americans with significantly more dairy and you may beef issues 15 . Inside context, a large-size prospective studies from the Chinese inhabitants in order to supplement the fresh new association’s evidence is undoubtedly expected. We, ergo, made use of investigation on China Health insurance and Nutrients Questionnaire (CHNS) to evaluate the connection between losing weight calcium supplements, magnesium, and you can phosphorus intakes and you will subsequent frequency away from stroke in Chinese grownups.